Proton Pump Inhibitors Accelerate Endothelial Senescence.

Letter by Marlicz et al Regarding Article, “Proton Pump Inhibitors Accelerate Endothelial Senescence”

Letter by Marlicz et al Regarding Article, “Proton Pump Inhibitors Accelerate Endothelial Senescence” We read with great interest the study by Yepuri et al on the effects of proton pump inhibitors (PPIs) on endothelial cells. The investigators exposed human microvascular endothelial cells to PPIs and observed reduced cell proliferation, a decrease in NO, and impaired proteostasis. Moreover, num...

Letter by Marlicz et al Regarding Article, "Proton Pump Inhibitors Accelerate Endothelial Senescence".

Letter by Marlicz et al Regarding Article, “Proton Pump Inhibitors Accelerate Endothelial Senescence” We read with great interest the study by Yepuri et al on the effects of proton pump inhibitors (PPIs) on endothelial cells. The investigators exposed human microvascular endothelial cells to PPIs and observed reduced cell proliferation, a decrease in NO, and impaired proteostasis. Moreover, num...

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

Correction to: Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction.

Preeclampsia is a severe complication of pregnancy. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin are secreted in excess from the placenta, causing hypertension, endothelial dysfunction, and multiorgan injury. Oxidative stress and vascular inflammation exacerbate the endothelial injury. A drug that can block these pathophysiological steps would be an at...

CONTINUING EDuCAtiON Review of the Clopidogrel - Proton Pump inhibitor interaction

OBjECTiVES 1. Describe the proposed mechanism of the interaction between clopidogrel and proton pump inhibitors. 2. Summarize the pharmacologic/pharmacodynamic evidence for the interaction between clopidogrel and proton pump inhibitors. 3. Summarize the clinical evidence for the interaction between clopidogrel and proton pump inhibitors. 4. Describe the food and Drug Administration’s updated wa...